Denis Boudreau and Wayne Dick presented on why browser zoom sucks, firstly from the point of view of testing with WCAG, and then from a low-vision user's point of view.
I've noticed a bug in Webkit browsers that impacts accessibility: Zooming in does not trigger media queries. Responsive design techniques can really help people who zoom in with their browser, but not in Chrome or Safari at the moment.
Layouts are becoming an issue again. The (browser) landscape is changing, as are the fashion in layouts, but not really in unison. I can understand giving a greater weight towards design aspects, and maintaining the grid, however, I find the timing curious, as these changes seem likely to be obsolete soon.